The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for TRPC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRPC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRPC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:142,447,330–142,448,346 | 276.0 kb | Distal (>10kb) Multiome | 859 | |
| chr3:142,568,423–142,569,093 | 155.4 kb | Distal (>10kb) Multiome | 163 | |
| chr3:142,578,301–142,579,268 | 145.2 kb | Distal (>10kb) Multiome | 1066 | |
| chr3:142,595,928–142,596,960 | 127.7 kb | Distal (>10kb) Multiome | 962 | |
| chr3:142,723,641–142,725,348 | 285 bp | At TSS Multiome | 876 | |
| chr3:142,863,026–142,863,734 | 139.3 kb | Distal (>10kb) Multiome | 186 | |
| chr3:142,866,818–142,867,310 | 143.0 kb | Distal (>10kb) Multiome | 187 | |
| chr3:142,888,221–142,889,512 | 164.8 kb | Distal (>10kb) Multiome | 691 | |
| chr3:142,962,519–142,964,437 | 239.6 kb | Distal (>10kb) Multiome | 781 | |
| chr3:143,000,964–143,002,299 | 277.5 kb | Distal (>10kb) Multiome | 1014 |
Genomic view of the TRPC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.