This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LNPEP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LNPEP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LNPEP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:96,661,819–96,663,768 | 273.9 kb | Distal (>10kb) Multiome | 856 | |
| chr5:96,702,491–96,703,472 | 233.2 kb | Distal (>10kb) Multiome | 828 | |
| chr5:96,807,053–96,808,809 | 127.8 kb | Distal (>10kb) Multiome | 1054 | |
| chr5:96,934,346–96,937,145 | 1.1 kb | Proximal (<10kb) Multiome | 1171 | |
| chr5:96,941,149–96,941,417 | 5.1 kb | Proximal (<10kb) | 4 | |
| chr5:96,944,808–96,945,217 | 8.7 kb | Proximal (<10kb) | 14 | |
| chr5:97,142,252–97,143,299 | 206.7 kb | Distal (>10kb) Multiome HiCAR | 308 | |
| chr5:97,182,741–97,184,087 | 247.5 kb | Distal (>10kb) Multiome | 963 | |
| chr5:97,192,555–97,193,805 | 257.1 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the LNPEP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.