Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ELOVL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOVL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOVL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:109,928,231–109,928,964 | 270.1 kb | Distal (>10kb) Multiome | 114 | |
| chr4:110,132,887–110,133,666 | 65.4 kb | Distal (>10kb) Multiome | 212 | |
| chr4:110,193,799–110,194,204 | 4.4 kb | Proximal (<10kb) | 438 | |
| chr4:110,195,911–110,198,252 | 2.0 kb | Proximal (<10kb) Multiome | 806 | |
| chr4:110,198,361–110,199,448 | 122 bp | At TSS Multiome | 817 | |
| chr4:110,411,354–110,412,301 | 213.2 kb | Distal (>10kb) Multiome | 372 |
Genomic view of the ELOVL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.