This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for VWF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VWF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VWF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:5,988,664–5,989,152 | 135.8 kb | Distal (>10kb) Multiome | 322 | |
| chr12:6,056,451–6,057,152 | 68.0 kb | Distal (>10kb) Multiome | 147 | |
| chr12:6,124,068–6,125,228 | 55 bp | At TSS Multiome | 240 | |
| chr12:6,199,391–6,201,130 | 75.6 kb | Distal (>10kb) Multiome | 481 | |
| chr12:6,278,466–6,279,375 | 154.2 kb | Distal (>10kb) Multiome | 655 | |
| chr12:6,310,091–6,311,512 | 186.0 kb | Distal (>10kb) Multiome | 645 | |
| chr12:6,322,926–6,323,961 | 198.7 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,335,766–6,337,493 | 212.0 kb | Distal (>10kb) Multiome | 962 | |
| chr12:6,341,619–6,342,234 | 217.5 kb | Distal (>10kb) Multiome | 657 | |
| chr12:6,363,292–6,364,138 | 238.9 kb | Distal (>10kb) Multiome | 718 | |
| chr12:6,370,899–6,371,535 | 246.6 kb | Distal (>10kb) Multiome | 572 | |
| chr12:6,375,204–6,377,302 | 250.8 kb | Distal (>10kb) Multiome | 601 | |
| chr12:6,383,790–6,384,442 | 259.4 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the VWF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.