Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CREBRF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREBRF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREBRF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:172,765,066–172,765,738 | 291.0 kb | Distal (>10kb) Multiome | 748 | |
| chr5:172,769,970–172,772,642 | 285.2 kb | Distal (>10kb) Multiome | 1190 | |
| chr5:172,828,888–172,829,516 | 227.1 kb | Distal (>10kb) Multiome | 139 | |
| chr5:172,833,492–172,835,141 | 222.1 kb | Distal (>10kb) Multiome | 673 | |
| chr5:172,941,457–172,942,000 | 114.6 kb | Distal (>10kb) Multiome | 22 | |
| chr5:172,958,380–172,959,872 | 97.1 kb | Distal (>10kb) Multiome | 868 | |
| chr5:172,983,384–172,984,597 | 72.6 kb | Distal (>10kb) Multiome | 848 | |
| chr5:173,055,699–173,057,854 | 923 bp | At TSS Multiome | 1049 | |
| chr5:173,058,305–173,058,632 | 1.9 kb | Proximal (<10kb) | 17 | |
| chr5:173,144,311–173,145,555 | 88.4 kb | Distal (>10kb) Multiome | 967 | |
| chr5:173,234,580–173,235,384 | 178.6 kb | Distal (>10kb) Multiome | 307 | |
| chr5:173,245,361–173,246,026 | 189.4 kb | Distal (>10kb) Multiome | 109 | |
| chr5:173,283,642–173,284,193 | 227.6 kb | Distal (>10kb) Multiome | 911 | |
| chr5:173,293,791–173,294,435 | 237.8 kb | Distal (>10kb) Multiome | 433 | |
| chr5:173,327,090–173,330,477 | 273.4 kb | Distal (>10kb) Multiome | 1064 |
Genomic view of the CREBRF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.