This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for IFT88. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT88 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT88, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,414,810–20,415,479 | 152.0 kb | Distal (>10kb) Multiome | 89 | |
| chr13:20,525,162–20,526,319 | 41.3 kb | Distal (>10kb) Multiome | 695 | |
| chr13:20,566,412–20,567,667 | 78 bp | At TSS Multiome | 901 | |
| chr13:20,703,037–20,704,890 | 137.1 kb | Distal (>10kb) Multiome | 620 | |
| chr13:20,773,202–20,774,439 | 206.8 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the IFT88 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.