Enables ATP binding activity and protein kinase activity. Involved in several processes, including interleukin-1-mediated signaling pathway; protein modification process; and regulation of DNA-templated transcription. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RPS6KA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:90,816,013–90,817,051 | 244.2 kb | Distal (>10kb) Multiome | 233 | |
| chr14:90,827,894–90,828,472 | 232.4 kb | Distal (>10kb) Multiome | 550 | |
| chr14:91,059,736–91,061,424 | 199 bp | At TSS Multiome | 848 | |
| chr14:91,113,925–91,114,783 | 53.6 kb | Distal (>10kb) Multiome | 710 | |
| chr14:91,252,762–91,254,136 | 192.7 kb | Distal (>10kb) Multiome | 429 | |
| chr14:91,264,238–91,265,162 | 204.0 kb | Distal (>10kb) Multiome | 276 | |
| chr14:91,302,942–91,304,213 | 242.8 kb | Distal (>10kb) Multiome | 215 |
Genomic view of the RPS6KA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.