Predicted to be involved in embryonic skeletal system development. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIAA1217. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA1217 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA1217, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:24,202,269–24,202,678 | 6.5 kb | Proximal (<10kb) | 102 | |
| chr10:24,208,276–24,209,690 | 178 bp | At TSS Multiome | 528 | |
| chr10:24,382,881–24,384,199 | 174.4 kb | Distal (>10kb) Multiome HiCAR | 521 | |
| chr10:24,470,087–24,471,206 | 261.6 kb | Distal (>10kb) Multiome | 271 | |
| chr10:25,933,585–25,935,356 | 1725.2 kb | Distal (>10kb) Multiome HiCAR | 425 |
Genomic view of the KIAA1217 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.