Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GRIK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:36,736,272–36,736,888 | 297.9 kb | Distal (>10kb) Multiome | 32 | |
| chr1:36,764,371–36,765,397 | 269.5 kb | Distal (>10kb) Multiome | 194 | |
| chr1:36,770,003–36,772,181 | 264.0 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr1:36,942,239–36,942,799 | 92.0 kb | Distal (>10kb) Multiome | 36 | |
| chr1:37,015,460–37,016,752 | 18.2 kb | Distal (>10kb) Multiome | 198 | |
| chr1:37,034,087–37,034,983 | 58 bp | At TSS Multiome | 164 | |
| chr1:37,036,130–37,036,329 | 1.6 kb | Proximal (<10kb) | 133 | |
| chr1:37,186,281–37,186,777 | 152.0 kb | Distal (>10kb) Multiome | 76 |
Genomic view of the GRIK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.