Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:179,652,424–179,653,975 | 949.1 kb | Distal (>10kb) Multiome HiCAR | 805 | |
| chr3:179,868,079–179,869,236 | 733.5 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr3:180,035,868–180,037,708 | 565.1 kb | Distal (>10kb) Multiome HiCAR | 462 | |
| chr3:180,134,684–180,136,449 | 466.7 kb | Distal (>10kb) Multiome HiCAR | 202 | |
| chr3:180,203,655–180,204,838 | 397.9 kb | Distal (>10kb) Multiome HiCAR | 176 | |
| chr3:180,601,567–180,602,844 | 3 bp | At TSS Multiome | 891 | |
| chr3:180,678,942–180,680,367 | 77.4 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the TTC14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.