This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for TP53BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:43,330,217–43,330,762 | 180.1 kb | Distal (>10kb) Multiome | 845 | |
| chr15:43,370,765–43,371,726 | 139.3 kb | Distal (>10kb) Multiome | 774 | |
| chr15:43,492,229–43,492,558 | 568 bp | At TSS | 99 | |
| chr15:43,492,673–43,493,432 | 17.4 kb | Distal (>10kb) Multiome | 544 | |
| chr15:43,510,550–43,511,326 | 258 bp | At TSS Multiome | 683 | |
| chr15:43,746,005–43,746,833 | 235.8 kb | Distal (>10kb) Multiome | 588 | |
| chr15:43,776,241–43,777,647 | 266.6 kb | Distal (>10kb) Multiome | 761 | |
| chr15:43,791,747–43,792,642 | 281.6 kb | Distal (>10kb) Multiome | 821 |
Genomic view of the TP53BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.