Predicted to enable protein sequestering activity. Predicted to be involved in several processes, including determination of adult lifespan; hair follicle development; and skeletal muscle fiber development. Predicted to be active in cytoplasm. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NORAD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NORAD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NORAD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,769,101–35,769,560 | 281.7 kb | Distal (>10kb) Multiome | 415 | |
| chr20:35,771,622–35,772,463 | 278.9 kb | Distal (>10kb) Multiome | 998 | |
| chr20:35,953,663–35,955,230 | 96.4 kb | Distal (>10kb) Multiome | 1166 | |
| chr20:36,010,700–36,011,324 | 40.1 kb | Distal (>10kb) Multiome | 70 | |
| chr20:36,050,468–36,051,316 | 41 bp | At TSS Multiome | 1033 | |
| chr20:36,064,282–36,065,619 | 13.8 kb | Distal (>10kb) Multiome | 798 | |
| chr20:36,092,411–36,092,942 | 41.6 kb | Distal (>10kb) Multiome | 320 | |
| chr20:36,154,232–36,155,251 | 103.6 kb | Distal (>10kb) Multiome | 526 | |
| chr20:36,259,130–36,259,999 | 208.5 kb | Distal (>10kb) Multiome | 159 | |
| chr20:36,306,218–36,306,746 | 255.3 kb | Distal (>10kb) Multiome | 148 |
Genomic view of the NORAD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.