This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for ACAD10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACAD10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACAD10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:111,404,305–111,407,139 | 280.4 kb | Distal (>10kb) Multiome | 928 | |
| chr12:111,597,725–111,600,125 | 86.5 kb | Distal (>10kb) Multiome | 973 | |
| chr12:111,685,452–111,686,504 | 58 bp | At TSS Multiome | 858 | |
| chr12:111,766,539–111,767,436 | 80.8 kb | Distal (>10kb) Multiome | 732 | |
| chr12:111,775,668–111,776,178 | 89.9 kb | Distal (>10kb) Multiome | 448 | |
| chr12:111,841,636–111,842,766 | 156.0 kb | Distal (>10kb) Multiome | 963 | |
| chr12:111,967,710–111,968,344 | 282.0 kb | Distal (>10kb) Multiome | 26 |
Genomic view of the ACAD10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.