DE-8 ›

DE-8.17

Submodule 10 genes

Cytoskeletal organization and cell-cell adhesion

This module comprises 10 genes including PI4KA, PXDN, CELSR1, SH3PXD2B, and ADCY7, with enriched terms related to cytoskeletal organization and cell-cell adhesion. Knockdown of SOX17, EOMESODERMIN, and FOXA2 activates this module. Knockdown of GATA4, GATA6, and CDX2 represses this module.

Key terms: lateral sprouting involved in lung morphogenesis symbiont-mediated perturbation of host membrane endoplasmic reticulum polarization actin filament bundle retrograde transport Notable genes: PI4KA PXDN CELSR1 SH3PXD2B ADCY7 PHF20 ALPK3 SHTN1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (10)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact