Enables several functions, including BAT3 complex binding activity; peptidase activity; and proteasome binding activity. Involved in several processes, including maintenance of unfolded protein; regulation of DNA-templated transcription; and regulation of catabolic process. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for USP13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:179,450,888–179,452,034 | 201.5 kb | Distal (>10kb) Multiome | 580 | |
| chr3:179,504,159–179,505,204 | 148.4 kb | Distal (>10kb) Multiome | 128 | |
| chr3:179,526,783–179,527,418 | 125.9 kb | Distal (>10kb) Multiome | 358 | |
| chr3:179,562,395–179,564,138 | 90.2 kb | Distal (>10kb) Multiome | 866 | |
| chr3:179,604,200–179,605,304 | 48.3 kb | Distal (>10kb) Multiome | 786 | |
| chr3:179,608,248–179,609,637 | 44.2 kb | Distal (>10kb) Multiome | 176 | |
| chr3:179,649,688–179,649,856 | 3.2 kb | Proximal (<10kb) | 116 | |
| chr3:179,652,424–179,653,975 | 7 bp | At TSS Multiome | 805 | |
| chr3:179,654,133–179,654,707 | 1.1 kb | Proximal (<10kb) | 232 | |
| chr3:179,868,079–179,869,236 | 215.6 kb | Distal (>10kb) Multiome | 140 | |
| chr3:180,601,567–180,602,844 | 949.1 kb | Distal (>10kb) Multiome HiCAR | 891 | |
| chr3:180,678,942–180,680,367 | 1026.5 kb | Distal (>10kb) Multiome HiCAR | 682 |
Genomic view of the USP13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.