Transcription factors with Perturb-seq knockdown data for RAB33B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB33B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB33B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,159,062–139,160,313 | 294.2 kb | Distal (>10kb) Multiome | 133 | |
| chr4:139,176,009–139,179,224 | 275.9 kb | Distal (>10kb) Multiome | 1018 | |
| chr4:139,279,361–139,280,628 | 173.8 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 158.2 kb | Distal (>10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 152.6 kb | Distal (>10kb) Multiome | 912 | |
| chr4:139,453,063–139,454,584 | 111 bp | At TSS Multiome | 989 | |
| chr4:139,461,123–139,461,280 | 7.3 kb | Proximal (<10kb) | 21 | |
| chr4:139,555,161–139,557,952 | 101.4 kb | Distal (>10kb) Multiome | 818 | |
| chr4:139,656,647–139,657,308 | 203.0 kb | Distal (>10kb) Multiome | 322 | |
| chr4:139,665,282–139,666,449 | 211.8 kb | Distal (>10kb) Multiome | 844 | |
| chr4:139,667,275–139,669,052 | 214.3 kb | Distal (>10kb) Multiome | 181 | |
| chr4:139,669,155–139,671,298 | 216.0 kb | Distal (>10kb) Multiome | 252 | |
| chr4:139,734,753–139,735,998 | 281.1 kb | Distal (>10kb) Multiome | 441 |
Genomic view of the RAB33B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.