This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for MICU1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MICU1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MICU1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:72,328,158–72,328,974 | 297.6 kb | Distal (>10kb) Multiome | 491 | |
| chr10:72,331,701–72,332,670 | 293.9 kb | Distal (>10kb) Multiome | 707 | |
| chr10:72,353,679–72,355,474 | 271.2 kb | Distal (>10kb) Multiome HiCAR | 1081 | |
| chr10:72,364,187–72,364,837 | 261.7 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr10:72,365,363–72,366,008 | 260.4 kb | Distal (>10kb) Multiome HiCAR | 20 | |
| chr10:72,456,009–72,456,568 | 169.7 kb | Distal (>10kb) Multiome | 83 | |
| chr10:72,625,602–72,626,407 | 44 bp | At TSS Multiome | 819 | |
| chr10:72,691,777–72,692,827 | 66.0 kb | Distal (>10kb) Multiome | 676 | |
| chr10:72,759,040–72,759,484 | 133.2 kb | Distal (>10kb) Multiome | 35 |
Genomic view of the MICU1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.