ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]
Transcription factors with Perturb-seq knockdown data for ANO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:5,945,100–5,945,514 | at TSS | At TSS | 238 | |
| chr12:5,988,664–5,989,152 | 43.6 kb | Distal (>10kb) Multiome | 322 | |
| chr12:6,056,451–6,057,152 | 111.5 kb | Distal (>10kb) Multiome | 147 | |
| chr12:6,124,068–6,125,228 | 179.5 kb | Distal (>10kb) Multiome | 240 | |
| chr12:6,199,391–6,201,130 | 255.0 kb | Distal (>10kb) Multiome | 481 | |
| chr12:6,214,773–6,215,509 | 270.0 kb | Distal (>10kb) Multiome | 158 |
Genomic view of the ANO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.