FAF1

Fas associated factor 1 | CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

Member of: DE-8 DE-8.3 Developmental clusters: GC1

Biological processes 33 terms

CD95 death-inducing signaling complex (GO:0031265)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)Fas signaling pathway (GO:0036337)NF-kappaB binding (GO:0051059)NF-kappaB binding (GO:0051059)VCP-NPL4-UFD1 AAA ATPase complex (GO:0034098)cytoplasm (GO:0005737)cytosol (GO:0005829)endomembrane system (GO:0012505)endoplasmic reticulum (GO:0005783)heat shock protein binding (GO:0031072)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)nuclear envelope (GO:0005635)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)positive regulation of DNA replication (GO:0045740)positive regulation of apoptotic process (GO:0043065)positive regulation of protein catabolic process (GO:0045732)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein kinase binding (GO:0019901)protein kinase regulator activity (GO:0019887)regulation of protein catabolic process (GO:0042176)regulation of signal transduction (GO:0009966)ubiquitin binding (GO:0043130)ubiquitin binding (GO:0043130)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process (GO:0006511)

Expression (TPM)

TFs regulating FAF1 0 TFs

Transcription factors with Perturb-seq knockdown data for FAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FAF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:50,416,739–50,417,464	543.3 kb	Distal (>10kb) Multiome HiCAR	115
chr1:50,418,573–50,419,824	541.2 kb	Distal (>10kb) Multiome HiCAR	250
chr1:50,420,661–50,421,743	539.1 kb	Distal (>10kb) Multiome HiCAR	164
chr1:50,422,450–50,424,285	536.7 kb	Distal (>10kb) Multiome HiCAR	446
chr1:50,699,953–50,700,766	260.0 kb	Distal (>10kb) Multiome	230
chr1:50,931,080–50,931,894	28.8 kb	Distal (>10kb) Multiome	233
chr1:50,959,563–50,960,794	4 bp	At TSS Multiome	976
chr1:50,968,048–50,970,309	8.2 kb	Proximal (<10kb) Multiome	1030
chr1:50,977,595–50,978,655	17.9 kb	Distal (>10kb) Multiome	755
chr1:51,234,986–51,237,165	276.0 kb	Distal (>10kb) Multiome	868

Genome Browser

Genomic view of the FAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.