IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]
Transcription factors with Perturb-seq knockdown data for IGSF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGSF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGSF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:118,772,170–118,773,201 | 262.0 kb | Distal (>10kb) Multiome | 228 | |
| chr3:118,810,579–118,811,137 | 223.8 kb | Distal (>10kb) Multiome | 139 | |
| chr3:119,034,159–119,035,267 | 63 bp | At TSS Multiome | 570 | |
| chr3:119,036,622–119,037,616 | 1.7 kb | Proximal (<10kb) | 37 | |
| chr3:119,173,189–119,173,912 | 138.8 kb | Distal (>10kb) Multiome | 150 | |
| chr3:119,206,295–119,207,798 | 172.3 kb | Distal (>10kb) Multiome | 256 | |
| chr3:119,210,998–119,211,738 | 176.7 kb | Distal (>10kb) Multiome | 234 | |
| chr3:119,240,068–119,241,279 | 206.1 kb | Distal (>10kb) Multiome | 820 | |
| chr3:119,241,393–119,241,941 | 207.0 kb | Distal (>10kb) Multiome | 393 | |
| chr3:119,293,740–119,295,412 | 259.4 kb | Distal (>10kb) Multiome | 540 | |
| chr3:119,322,394–119,324,118 | 288.3 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the IGSF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.