Transcription factors with Perturb-seq knockdown data for ENSG00000214955. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000214955 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000214955, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,915,370–33,916,223 | 289.2 kb | Distal (>10kb) Multiome | 730 | |
| chr21:34,072,589–34,075,396 | 130.1 kb | Distal (>10kb) Multiome | 822 | |
| chr21:34,195,451–34,195,694 | 9.4 kb | Proximal (<10kb) | 35 | |
| chr21:34,201,488–34,202,922 | 3.0 kb | Proximal (<10kb) Multiome | 669 |
Genomic view of the ENSG00000214955 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.