Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1RL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1RL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1RL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,821,268–6,822,155 | 287.5 kb | Distal (>10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 283.5 kb | Distal (>10kb) Multiome | 404 | |
| chr12:6,828,101–6,829,966 | 279.6 kb | Distal (>10kb) Multiome | 689 | |
| chr12:6,851,017–6,853,279 | 256.9 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 241.7 kb | Distal (>10kb) Multiome | 887 | |
| chr12:6,871,062–6,874,199 | 236.9 kb | Distal (>10kb) Multiome | 947 | |
| chr12:6,890,735–6,891,820 | 218.0 kb | Distal (>10kb) Multiome | 908 | |
| chr12:6,904,217–6,905,282 | 204.4 kb | Distal (>10kb) Multiome | 566 | |
| chr12:6,914,274–6,914,898 | 194.8 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,924,156–6,924,592 | 184.7 kb | Distal (>10kb) Multiome | 458 | |
| chr12:6,925,828–6,926,431 | 183.2 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,927,411–6,928,051 | 181.4 kb | Distal (>10kb) Multiome | 493 | |
| chr12:6,936,709–6,938,342 | 171.2 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:6,942,356–6,945,492 | 165.0 kb | Distal (>10kb) Multiome HiCAR | 1205 | |
| chr12:6,945,587–6,947,099 | 162.8 kb | Distal (>10kb) Multiome HiCAR | 618 | |
| chr12:6,961,769–6,963,542 | 146.0 kb | Distal (>10kb) Multiome | 682 | |
| chr12:6,964,932–6,965,569 | 144.0 kb | Distal (>10kb) Multiome | 549 | |
| chr12:6,970,111–6,971,189 | 138.5 kb | Distal (>10kb) Multiome | 899 | |
| chr12:7,018,028–7,019,126 | 90.5 kb | Distal (>10kb) Multiome | 824 | |
| chr12:7,108,059–7,109,582 | 96 bp | At TSS Multiome | 818 | |
| chr12:7,113,384–7,113,587 | 4.2 kb | Proximal (<10kb) | 132 | |
| chr12:7,129,788–7,131,412 | 21.1 kb | Distal (>10kb) Multiome HiCAR | 619 | |
| chr12:7,188,394–7,190,508 | 79.3 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the C1RL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.