This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for ANKRD26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:26,860,047–26,861,781 | 239.4 kb | Distal (>10kb) Multiome | 923 | |
| chr10:26,923,645–26,924,112 | 176.6 kb | Distal (>10kb) Multiome | 66 | |
| chr10:27,015,228–27,016,107 | 84.8 kb | Distal (>10kb) Multiome | 15 | |
| chr10:27,090,618–27,091,051 | 9.4 kb | Proximal (<10kb) | 11 | |
| chr10:27,099,907–27,101,042 | 88 bp | At TSS Multiome | 756 | |
| chr10:27,153,856–27,156,360 | 54.8 kb | Distal (>10kb) Multiome | 970 | |
| chr10:27,240,222–27,241,262 | 140.1 kb | Distal (>10kb) Multiome | 831 | |
| chr10:27,241,284–27,242,441 | 141.7 kb | Distal (>10kb) Multiome | 851 | |
| chr10:27,252,226–27,253,021 | 152.1 kb | Distal (>10kb) Multiome | 405 | |
| chr10:27,258,839–27,259,511 | 158.7 kb | Distal (>10kb) Multiome | 220 | |
| chr10:27,319,712–27,320,433 | 219.5 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the ANKRD26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.