RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for RICTOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RICTOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RICTOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:38,809,383–38,810,097 | 264.5 kb | Distal (>10kb) Multiome | 352 | |
| chr5:38,844,903–38,847,060 | 228.4 kb | Distal (>10kb) Multiome | 868 | |
| chr5:39,064,559–39,065,016 | 9.4 kb | Proximal (<10kb) | 22 | |
| chr5:39,072,981–39,075,472 | 84 bp | At TSS Multiome | 1130 | |
| chr5:39,080,660–39,080,907 | 6.3 kb | Proximal (<10kb) | 246 | |
| chr5:40,797,344–40,798,944 | 1723.8 kb | Distal (>10kb) Multiome HiCAR | 949 |
Genomic view of the RICTOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.