This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2018]
Transcription factors with Perturb-seq knockdown data for PI4KA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PI4KA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PI4KA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,606,015–20,606,540 | 252.4 kb | Distal (>10kb) Multiome | 411 | |
| chr22:20,702,218–20,703,674 | 155.8 kb | Distal (>10kb) Multiome | 438 | |
| chr22:20,857,959–20,859,512 | 44 bp | At TSS Multiome | 901 | |
| chr22:20,885,370–20,886,088 | 27.0 kb | Distal (>10kb) Multiome | 749 | |
| chr22:20,916,779–20,918,119 | 58.4 kb | Distal (>10kb) Multiome | 985 | |
| chr22:20,957,739–20,958,321 | 99.0 kb | Distal (>10kb) Multiome | 346 | |
| chr22:20,979,087–20,980,257 | 120.7 kb | Distal (>10kb) Multiome | 435 | |
| chr22:20,981,807–20,982,763 | 123.3 kb | Distal (>10kb) Multiome | 1020 | |
| chr22:21,001,335–21,002,797 | 143.2 kb | Distal (>10kb) Multiome | 1021 | |
| chr22:21,013,880–21,015,021 | 155.5 kb | Distal (>10kb) Multiome | 661 | |
| chr22:21,045,516–21,046,316 | 187.0 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the PI4KA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.