The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CELSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CELSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CELSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:46,249,918–46,250,866 | 287.3 kb | Distal (>10kb) Multiome | 831 | |
| chr22:46,262,531–46,263,383 | 274.7 kb | Distal (>10kb) Multiome | 169 | |
| chr22:46,267,542–46,268,277 | 269.7 kb | Distal (>10kb) Multiome | 725 | |
| chr22:46,296,072–46,297,498 | 240.8 kb | Distal (>10kb) Multiome | 810 | |
| chr22:46,335,274–46,336,005 | 202.0 kb | Distal (>10kb) Multiome | 911 | |
| chr22:46,536,494–46,538,050 | 25 bp | At TSS Multiome | 337 | |
| chr22:46,538,230–46,538,777 | 610 bp | At TSS | 260 | |
| chr22:46,542,356–46,542,603 | 4.7 kb | Proximal (<10kb) | 357 | |
| chr22:46,563,410–46,564,218 | 26.2 kb | Distal (>10kb) Multiome | 541 | |
| chr22:46,576,506–46,577,542 | 39.5 kb | Distal (>10kb) Multiome | 332 | |
| chr22:46,627,272–46,627,735 | 90.0 kb | Distal (>10kb) Multiome | 93 | |
| chr22:46,737,592–46,739,215 | 200.7 kb | Distal (>10kb) Multiome | 596 | |
| chr22:46,762,030–46,763,235 | 225.0 kb | Distal (>10kb) Multiome | 920 | |
| chr22:46,803,079–46,803,635 | 265.8 kb | Distal (>10kb) Multiome | 349 |
Genomic view of the CELSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.