This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RASAL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASAL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASAL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:178,041,441–178,041,859 | 299.8 kb | Distal (>10kb) Multiome | 6 | |
| chr1:178,042,486–178,043,383 | 298.5 kb | Distal (>10kb) Multiome | 8 | |
| chr1:178,050,912–178,051,905 | 290.0 kb | Distal (>10kb) Multiome | 165 | |
| chr1:178,061,128–178,061,718 | 280.1 kb | Distal (>10kb) Multiome | 212 | |
| chr1:178,093,136–178,094,997 | 247.7 kb | Distal (>10kb) Multiome | 839 | |
| chr1:178,266,434–178,267,291 | 74.6 kb | Distal (>10kb) Multiome | 137 | |
| chr1:178,283,034–178,284,259 | 57.9 kb | Distal (>10kb) Multiome | 213 | |
| chr1:178,341,245–178,341,573 | at TSS | At TSS | 223 | |
| chr1:178,344,376–178,344,730 | 2.9 kb | Proximal (<10kb) | 171 | |
| chr1:178,345,017–178,345,128 | 3.5 kb | Proximal (<10kb) | 96 | |
| chr1:178,541,715–178,543,543 | 201.4 kb | Distal (>10kb) Multiome | 856 | |
| chr1:178,581,331–178,581,873 | 240.2 kb | Distal (>10kb) Multiome | 139 |
Genomic view of the RASAL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.