Predicted to enable structural molecule activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell projection assembly. Predicted to be located in neuron projection; sperm fibrous sheath; and sperm principal piece. Predicted to be active in motile cilium. Implicated in spermatogenic failure 26. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TSGA10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSGA10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSGA10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:98,935,565–98,937,394 | 218.7 kb | Distal (>10kb) Multiome | 344 | |
| chr2:99,081,586–99,082,682 | 72.8 kb | Distal (>10kb) Multiome | 73 | |
| chr2:99,140,631–99,142,044 | 13.6 kb | Distal (>10kb) Multiome | 976 | |
| chr2:99,154,503–99,155,535 | 33 bp | At TSS Multiome | 1013 | |
| chr2:99,180,725–99,181,615 | 26.2 kb | Distal (>10kb) Multiome | 1014 | |
| chr2:99,335,843–99,338,098 | 182.5 kb | Distal (>10kb) Multiome | 1129 |
Genomic view of the TSGA10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.