Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NRIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:14,986,951–14,988,453 | 77.4 kb | Distal (>10kb) Multiome | 190 | |
| chr21:15,058,792–15,059,207 | 5.8 kb | Proximal (<10kb) | 128 | |
| chr21:15,060,866–15,061,118 | 3.9 kb | Proximal (<10kb) | 122 | |
| chr21:15,063,855–15,066,197 | 27 bp | At TSS Multiome | 762 | |
| chr21:15,290,094–15,290,950 | 225.7 kb | Distal (>10kb) Multiome HiCAR | 172 |
Genomic view of the NRIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.