This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for JAK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JAK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JAK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:64,965,270–64,967,021 | 101.1 kb | Distal (>10kb) Multiome | 764 | |
| chr1:65,002,269–65,003,167 | 64.8 kb | Distal (>10kb) Multiome | 584 | |
| chr1:65,065,952–65,068,343 | 1.0 kb | Proximal (<10kb) Multiome | 865 | |
| chr1:65,075,457–65,075,657 | 7.8 kb | Proximal (<10kb) | 176 | |
| chr1:65,147,108–65,150,062 | 80.1 kb | Distal (>10kb) Multiome | 912 | |
| chr1:65,253,859–65,255,712 | 186.9 kb | Distal (>10kb) Multiome | 756 | |
| chr1:65,265,365–65,266,424 | 198.3 kb | Distal (>10kb) Multiome | 602 | |
| chr1:65,308,757–65,310,566 | 242.3 kb | Distal (>10kb) Multiome | 950 | |
| chr1:66,532,636–66,534,688 | 1466.4 kb | Distal (>10kb) Multiome HiCAR | 428 |
Genomic view of the JAK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.