Enables enzyme binding activity; enzyme-substrate adaptor activity; and mRNA 3'-UTR binding activity. Involved in cytidine to uridine editing; positive regulation of type I interferon-mediated signaling pathway; and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. Part of apolipoprotein B mRNA editing enzyme complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM47. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM47 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM47, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:40,629,348–40,630,967 | 50 bp | At TSS Multiome | 624 | |
| chr4:40,749,726–40,750,696 | 120.1 kb | Distal (>10kb) Multiome | 406 | |
| chr4:40,856,616–40,857,500 | 227.3 kb | Distal (>10kb) Multiome | 338 | |
| chr4:40,874,407–40,874,886 | 244.8 kb | Distal (>10kb) Multiome | 73 | |
| chr4:40,908,340–40,909,118 | 278.9 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the RBM47 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.