The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for ASB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:53,767,422–53,768,367 | 18.9 kb | Distal (>10kb) Multiome | 710 | |
| chr2:53,786,365–53,787,886 | 140 bp | At TSS Multiome | 999 | |
| chr2:53,859,343–53,860,396 | 73.0 kb | Distal (>10kb) Multiome | 238 | |
| chr2:53,970,071–53,971,956 | 184.3 kb | Distal (>10kb) Multiome | 992 | |
| chr2:53,973,080–53,973,900 | 186.7 kb | Distal (>10kb) Multiome | 37 |
Genomic view of the ASB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.