This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for COG6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COG6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COG6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:39,377,748–39,378,646 | 277.6 kb | Distal (>10kb) Multiome | 93 | |
| chr13:39,385,335–39,386,176 | 270.0 kb | Distal (>10kb) Multiome | 268 | |
| chr13:39,602,393–39,603,938 | 52.7 kb | Distal (>10kb) Multiome | 478 | |
| chr13:39,655,392–39,656,371 | 28 bp | At TSS Multiome | 690 | |
| chr13:40,680,324–40,681,411 | 1025.1 kb | Distal (>10kb) Multiome HiCAR | 281 |
Genomic view of the COG6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.