This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for ADCY7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:50,024,713–50,025,833 | 221.0 kb | Distal (>10kb) Multiome | 882 | |
| chr16:50,065,596–50,066,866 | 180.0 kb | Distal (>10kb) Multiome | 839 | |
| chr16:50,152,387–50,154,528 | 93.0 kb | Distal (>10kb) Multiome | 930 | |
| chr16:50,244,509–50,244,980 | 1.2 kb | Proximal (<10kb) | 126 | |
| chr16:50,245,572–50,246,768 | at TSS | At TSS | 520 | |
| chr16:50,250,000–50,250,272 | 3.9 kb | Proximal (<10kb) | 31 | |
| chr16:50,368,327–50,369,672 | 122.9 kb | Distal (>10kb) Multiome | 596 | |
| chr16:50,467,766–50,468,772 | 222.1 kb | Distal (>10kb) Multiome | 685 | |
| chr16:50,539,882–50,540,391 | 294.0 kb | Distal (>10kb) Multiome | 134 | |
| chr16:50,665,176–50,665,840 | 419.3 kb | Distal (>10kb) Multiome HiCAR | 469 |
Genomic view of the ADCY7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.