The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for SLIT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLIT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLIT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:168,943,810–168,944,597 | 357.0 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr5:169,083,300–169,083,998 | 217.5 kb | Distal (>10kb) Multiome | 300 | |
| chr5:169,299,757–169,302,060 | 45 bp | At TSS Multiome | 347 | |
| chr5:169,302,442–169,303,019 | 1.3 kb | Proximal (<10kb) | 182 | |
| chr5:169,503,731–169,504,763 | 203.1 kb | Distal (>10kb) Multiome | 222 | |
| chr5:169,528,729–169,529,472 | 227.9 kb | Distal (>10kb) Multiome | 127 | |
| chr5:169,583,341–169,584,242 | 282.6 kb | Distal (>10kb) Multiome | 667 |
Genomic view of the SLIT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.