This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for PXDN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PXDN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PXDN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:1,591,763–1,592,421 | 152.4 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr2:1,625,123–1,625,967 | 118.9 kb | Distal (>10kb) Multiome | 404 | |
| chr2:1,707,716–1,708,711 | 36.4 kb | Distal (>10kb) Multiome HiCAR | 383 | |
| chr2:1,742,682–1,745,219 | 56 bp | At TSS Multiome | 477 | |
| chr2:1,749,455–1,749,697 | 4.9 kb | Proximal (<10kb) | 8 | |
| chr2:1,750,735–1,751,565 | 6.2 kb | Proximal (<10kb) | 222 | |
| chr2:1,817,239–1,818,101 | 73.2 kb | Distal (>10kb) Multiome | 375 | |
| chr2:1,823,112–1,823,997 | 79.0 kb | Distal (>10kb) Multiome | 143 | |
| chr2:2,007,056–2,008,424 | 263.3 kb | Distal (>10kb) Multiome | 325 | |
| chr2:3,518,104–3,520,209 | 1774.7 kb | Distal (>10kb) Multiome HiCAR | 1083 |
Genomic view of the PXDN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.