HIP1
huntingtin interacting protein 1 | ILWEQ

The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Member of: DE-8 DE-8.4
Biological processes 72 terms
AP-2 adaptor complex binding (GO:0035612)Golgi apparatus (GO:0005794)Schaffer collateral - CA1 synapse (GO:0098685)actin binding (GO:0003779)actin filament binding (GO:0051015)actin filament binding (GO:0051015)actin filament organization (GO:0007015)apoptotic process (GO:0006915)apoptotic signaling pathway (GO:0097190)apoptotic signaling pathway (GO:0097190)clathrin binding (GO:0030276)clathrin binding (GO:0030276)clathrin coat assembly (GO:0048268)clathrin coat assembly (GO:0048268)clathrin coat assembly (GO:0048268)clathrin light chain binding (GO:0032051)clathrin light chain binding (GO:0032051)clathrin-cargo adaptor activity (GO:0035615)clathrin-cargo adaptor activity (GO:0035615)clathrin-coated vesicle (GO:0030136)clathrin-coated vesicle (GO:0030136)clathrin-coated vesicle membrane (GO:0030665)cortical actin cytoskeleton (GO:0030864)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)endocytosis (GO:0006897)endocytosis (GO:0006897)endomembrane system (GO:0012505)epidermal growth factor receptor binding (GO:0005154)glutamate receptor binding (GO:0035254)glutamatergic synapse (GO:0098978)membrane (GO:0016020)neurotransmitter receptor transport (GO:0099637)nucleus (GO:0005634)nucleus (GO:0005634)phosphatidylinositol binding (GO:0035091)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-3-phosphate binding (GO:0032266)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phospholipid binding (GO:0005543)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of platelet-derived growth factor receptor-beta signaling pathway (GO:2000588)positive regulation of platelet-derived growth factor receptor-beta signaling pathway (GO:2000588)positive regulation of platelet-derived growth factor receptor-beta signaling pathway (GO:2000588)positive regulation of receptor-mediated endocytosis (GO:0048260)positive regulation of receptor-mediated endocytosis (GO:0048260)postsynapse (GO:0098794)presynapse (GO:0098793)presynapse (GO:0098793)presynaptic modulation of chemical synaptic transmission (GO:0099171)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein stabilization (GO:0050821)protein stabilization (GO:0050821)regulation of apoptotic process (GO:0042981)regulation of apoptotic process (GO:0042981)regulation of endocytosis (GO:0030100)regulation of postsynaptic neurotransmitter receptor internalization (GO:0099149)structural constituent of cytoskeleton (GO:0005200)synapse (GO:0045202)
Expression (TPM)
HIP1 — as a Regulated Gene

TFs regulating HIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for HIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr7:75,486,016–75,486,644 252.6 kb Distal (>10kb) Multiome 434
chr7:75,527,536–75,528,568 210.8 kb Distal (>10kb) Multiome 667
chr7:75,531,374–75,531,886 207.3 kb Distal (>10kb) Multiome 161
chr7:75,546,305–75,547,063 192.4 kb Distal (>10kb) Multiome 150
chr7:75,638,467–75,640,092 99.3 kb Distal (>10kb) Multiome HiCAR 654
chr7:75,738,406–75,739,915 254 bp At TSS Multiome 795
chr7:75,778,655–75,779,512 40.2 kb Distal (>10kb) Multiome 54
chr7:75,780,667–75,781,151 41.9 kb Distal (>10kb) Multiome 106
chr7:75,788,149–75,788,821 49.5 kb Distal (>10kb) Multiome 95
chr7:75,878,577–75,879,573 140.0 kb Distal (>10kb) Multiome 883
chr7:75,914,282–75,915,911 176.1 kb Distal (>10kb) Multiome 1021
chr7:75,993,473–75,995,401 255.7 kb Distal (>10kb) Multiome 873

Genome Browser

Genomic view of the HIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr7:75,476,016 – 76,005,401
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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