The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CTPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:16,712,105–16,712,490 | 178 bp | At TSS | 387 | |
| chrX:16,712,602–16,712,792 | at TSS | At TSS | 456 | |
| chrX:16,719,154–16,719,979 | 6.6 kb | Proximal (<10kb) Multiome | 716 | |
| chrX:16,771,090–16,772,164 | 58.7 kb | Distal (>10kb) Multiome | 626 | |
| chrX:16,786,080–16,787,269 | 73.4 kb | Distal (>10kb) Multiome | 646 | |
| chrX:16,869,468–16,871,503 | 157.5 kb | Distal (>10kb) Multiome | 687 | |
| chrX:16,946,195–16,947,346 | 233.7 kb | Distal (>10kb) Multiome | 329 | |
| chrX:17,007,183–17,007,806 | 294.5 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the CTPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.