The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AKT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:243,487,408–243,488,260 | 363.3 kb | Distal (>10kb) Multiome HiCAR | 178 | |
| chr1:243,489,570–243,490,456 | 361.2 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr1:243,848,989–243,851,603 | 364 bp | At TSS Multiome | 630 | |
| chr1:243,855,605–243,856,094 | 4.5 kb | Proximal (<10kb) | 26 | |
| chr1:243,917,045–243,917,829 | 66.4 kb | Distal (>10kb) Multiome | 409 | |
| chr1:244,047,471–244,050,335 | 197.3 kb | Distal (>10kb) Multiome | 939 | |
| chr1:244,054,108–244,055,007 | 203.4 kb | Distal (>10kb) Multiome | 151 |
Genomic view of the AKT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.