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DE-8.4

Submodule 20 genes

Anchoring junction assembly and cell adhesion

This module contains 20 genes including GLI2, HIP1, WNT5B, USP13, and GRIK3, with enrichment for anchoring junction components. The top 3 TFs whose knockdown activates this module are SOX17, FOXA2, and GATA4. The top 3 TFs whose knockdown represses this module are OCT4, NANOG, and KLF4.

Key terms: cell adhesion morphogenesis of an epithelium spinal cord ventral commissure morphogenesis ventral spinal cord interneuron differentiation Notable genes: GLI2 HIP1 WNT5B USP13 GRIK3 PTPRS TBCD TNS3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (20)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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