Involved in spliceosomal complex assembly. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RSRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RSRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RSRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,232,067–25,232,905 | 14.9 kb | Distal (>10kb) Multiome | 757 | |
| chr1:25,233,146–25,233,599 | 14.1 kb | Distal (>10kb) Multiome | 493 | |
| chr1:25,239,634–25,240,475 | 7.5 kb | Proximal (<10kb) Multiome | 897 | |
| chr1:25,245,953–25,246,322 | 1.1 kb | Proximal (<10kb) | 153 | |
| chr1:25,246,452–25,248,229 | 191 bp | At TSS Multiome | 1054 | |
| chr1:25,250,194–25,250,400 | 2.7 kb | Proximal (<10kb) | 18 | |
| chr1:25,253,726–25,254,271 | 6.3 kb | Proximal (<10kb) | 90 | |
| chr1:25,338,116–25,338,949 | 91.0 kb | Distal (>10kb) Multiome | 803 | |
| chr1:25,429,935–25,431,604 | 182.8 kb | Distal (>10kb) Multiome | 845 | |
| chr1:25,543,218–25,544,436 | 296.2 kb | Distal (>10kb) Multiome | 569 |
Genomic view of the RSRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.