'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for HHAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HHAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HHAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:209,888,562–209,889,538 | 440.0 kb | Distal (>10kb) Multiome HiCAR | 75 | |
| chr1:210,232,393–210,234,634 | 96.1 kb | Distal (>10kb) Multiome | 604 | |
| chr1:210,250,530–210,250,970 | 78.1 kb | Distal (>10kb) Multiome | 203 | |
| chr1:210,251,093–210,253,535 | 77.4 kb | Distal (>10kb) Multiome | 576 | |
| chr1:210,291,920–210,292,942 | 36.4 kb | Distal (>10kb) Multiome | 518 | |
| chr1:210,310,943–210,312,049 | 17.5 kb | Distal (>10kb) Multiome | 437 | |
| chr1:210,328,482–210,330,700 | 68 bp | At TSS Multiome | 743 | |
| chr1:210,373,253–210,375,038 | 45.4 kb | Distal (>10kb) Multiome | 933 | |
| chr1:211,133,108–211,134,829 | 805.3 kb | Distal (>10kb) Multiome HiCAR | 739 |
Genomic view of the HHAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.