chr16:8,965,943–8,966,445

chr16 : 8,965,943 – 8,966,445

502 bp 109 TFs 6 linked genes

This 502 bp open chromatin element is linked to 6 target genes and is bound by 109 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
USP7		2.5 kb	Proximal	Proximity
CARHSP1		97.5 kb	Distal	Multiome
HAPSTR1		125.5 kb	Distal	Multiome
PMM2		168.3 kb	Distal	Multiome
TMEM186		168.6 kb	Distal	Multiome
ABAT		291.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

109 transcription factors

ARID1A 3 datasets

ChIP HAP1 GSE108387.ARID1A.HAP1 244 bp overlap

ChIP endometrial-epithelial-cells GSE106660.ARID1A.endometrial-epithelial-cells 490 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.ARID1A.endometrial-epithelial-cells_KO 454 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 217 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 502 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 394 bp overlap

BCOR 4 datasets

ChIP WA01 GSE104690.BCOR.WA01 420 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 263 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 307 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 498 bp overlap

BORCS8,MEF2B 1 dataset

ChIP HepG2 ENCFF255VGS 103 bp overlap

BRD4 3 datasets

ChIP HAP1 GSE108387.BRD4.HAP1 245 bp overlap

ChIP MDA-MB-231_DMSO GSE116879.BRD4.MDA-MB-231_DMSO 304 bp overlap

ChIP MDA-MB-231_DMSO_rDNA GSE116879.BRD4.MDA-MB-231_DMSO_rDNA 304 bp overlap

ChIP HepG2 ENCFF987NRP 98 bp overlap

CDKN1B 1 dataset

ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 182 bp overlap

CHD7 2 datasets

ChIP H1 ENCFF126NLU 502 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 252 bp overlap

CREB1 1 dataset

ChIP WA01 ENCSR000BSN.CREB1.WA01 104 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 353 bp overlap

ChIP HAP1_clone21_CTCF-CRISPR GSE152721.CTCF.HAP1_clone21_CTCF-CRISPR 231 bp overlap

CTNNB1 1 dataset

ChIP hESC_YAP-_activinA_15h GSE99202.CTNNB1.hESC_YAP-_activinA_15h 370 bp overlap

CUX1 3 datasets

ChIP Hep-G2 ENCSR049KIZ.CUX1.Hep-G2 159 bp overlap

ChIP MCF-7 ENCFF779ATB 275 bp overlap

ChIP MCF-7 ENCSR017CEO.CUX1.MCF-7 286 bp overlap

ChIP NTERA2 GSE58641.DDX5.NTERA2 178 bp overlap

ChIP WA01 GSE94322.DUX4.WA01 152 bp overlap

ChIP WTC11 ENCFF449LLF 409 bp overlap

Motif DE_12h DE_12h-E2F7_MA0758.1 14 bp overlap

Motif DE_12h DE_12h-EBF3_MA1637.2 9 bp overlap

Motif DE_12h DE_12h-EHF_MA0598.4 9 bp overlap

Motif DE_12h DE_12h-ELF1_MA0473.4 9 bp overlap

Motif DE_12h DE_12h-ELF3_MA0640.3 9 bp overlap

EP300 2 datasets

ChIP H1 ENCFF927IYK 297 bp overlap

ChIP WA01 ENCSR000BKK.EP300.WA01 255 bp overlap

ChIP hESC ENCSR534VHI.ETS1.hESC 122 bp overlap

Motif DE_12h DE_12h-ETV1_MA0761.3 9 bp overlap

ChIP WTC11 ENCFF812SCD 385 bp overlap

Motif DE_12h DE_12h-Ebf2_MA1604.2 9 bp overlap

Motif DE_12h DE_12h-Erg_MA0474.4 10 bp overlap

ChIP CFPAC-1 GSE119930.FOS.CFPAC-1 355 bp overlap

FOXA1 4 datasets

ChIP ZR751 GSE72249.FOXA1.ZR751 133 bp overlap

ChIP ZR751_DEX GSE72249.FOXA1.ZR751_DEX 94 bp overlap

ChIP ZR751_E2 GSE72249.FOXA1.ZR751_E2 147 bp overlap

ChIP breast_tumor_Male_13 GSE104399.FOXA1.breast_tumor_Male_13 148 bp overlap

FOXA2 1 dataset

ChIP CFPAC-1_EV GSE119930.FOXA2.CFPAC-1_EV 411 bp overlap

FOXK1 1 dataset

ChIP WTC11 ENCFF875IGU 384 bp overlap

FOXP1 1 dataset

ChIP H9 GSE31006.FOXP1.H9 199 bp overlap

FOXP4 1 dataset

ChIP WTC11 ENCFF708TAF 377 bp overlap

GABPA 1 dataset

Motif DE_12h DE_12h-GABPA_MA0062.4 10 bp overlap

GATA2 1 dataset

ChIP HepG2 ENCFF905PYM 98 bp overlap

GATA6 1 dataset

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 296 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 122 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 347 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 214 bp overlap

HDAC2 2 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 140 bp overlap

ChIP HepG2 ENCFF200ZII 279 bp overlap

HIF1A 1 dataset

ChIP BEAS-2B_arsenic GSE145834.HIF1A.BEAS-2B_arsenic 230 bp overlap

HMGXB4 1 dataset

ChIP HepG2 ENCFF032DND 502 bp overlap

Hand1 1 dataset

Motif DE_12h DE_12h-Hand1_MA2123.1 9 bp overlap

Hand1::Tcf3 1 dataset

Motif DE_12h DE_12h-Hand1Tcf3_MA0092.2 9 bp overlap

Hnf1A 1 dataset

Motif DE_12h DE_12h-Hnf1A_MA1991.2 10 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 483 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 502 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 502 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 442 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 444 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 502 bp overlap

ChIP H1 ENCFF621PNP 241 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 500 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 502 bp overlap

ChIP CFPAC-1 GSE119930.JUNB.CFPAC-1 446 bp overlap

JUND 2 datasets

ChIP H1 ENCFF010YXS 311 bp overlap

ChIP WA01 ENCSR000EBZ.JUND.WA01 209 bp overlap

KAT2B 1 dataset

ChIP Hep-G2 ENCSR620YNB.KAT2B.Hep-G2 123 bp overlap

KDM1A 3 datasets

ChIP K-562 ENCSR360HRA.KDM1A.K-562 215 bp overlap

ChIP K562 ENCFF128TYE 270 bp overlap

ChIP K562 ENCFF133OLU 267 bp overlap

ChIP hiPSC GSE56567.KLF4.hiPSC 182 bp overlap

Motif DE_12h DE_12h-Lef1_MA0768.3 8 bp overlap

ChIP WTC11 ENCFF223QFY 502 bp overlap

ChIP hESC_PRIMED GSE69646.MED1.hESC_PRIMED 282 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 402 bp overlap

NANOG 11 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 221 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 502 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 464 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 256 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 502 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 484 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 477 bp overlap

ChIP hESC GSE18292.NANOG.hESC 173 bp overlap

ChIP hESC GSE20650.NANOG.hESC 323 bp overlap

NFKB2 1 dataset

Motif DE_12h DE_12h-NFKB2_MA0778.2 11 bp overlap

NIPBL 2 datasets

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 248 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 194 bp overlap

NR2F1 1 dataset

ChIP GM12878 ENCSR514VYD.NR2F1.GM12878 300 bp overlap

PAX5 2 datasets

ChIP GM12878 ENCSR000BHD.PAX5.GM12878 177 bp overlap

ChIP GM12878 ENCSR000BHJ.PAX5.GM12878 153 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 453 bp overlap

PDX1 2 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 227 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 119 bp overlap

PHF21A 1 dataset

ChIP K562 ENCFF088QME 155 bp overlap

ChIP HCT-116_ab833 GSE101646.PHIP.HCT-116_ab833 232 bp overlap

POU5F1 16 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 502 bp overlap

ChIP GM23338 ENCFF333SNB 311 bp overlap

ChIP H1 ENCFF698ZAP 205 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 502 bp overlap

ChIP NCCIT GSE36134.POU5F1.NCCIT 309 bp overlap

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 502 bp overlap

ChIP OSKM GSE81899.POU5F1.OSKM 279 bp overlap

ChIP WA01 ENCSR000BMU.POU5F1.WA01 273 bp overlap

ChIP WA09 GSE105028.POU5F1.WA09 371 bp overlap

ChIP WA09_heat-shock GSE105028.POU5F1.WA09_heat-shock 308 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 294 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 405 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 502 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 311 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 326 bp overlap

ChIP neuron_bipolar_doxy_4d ENCSR362VCG.POU5F1.neuron_bipolar_doxy_4d 108 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 502 bp overlap

RAD21 2 datasets

ChIP HAP1 GSE152721.RAD21.HAP1 234 bp overlap

ChIP WA09_heat-shock GSE105028.RAD21.WA09_heat-shock 171 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 228 bp overlap

RNF2 2 datasets

ChIP HUES-64 GSE104059.RNF2.HUES-64 185 bp overlap

ChIP WA09 GSE105028.RNF2.WA09 318 bp overlap

RXRA 2 datasets

ChIP JMSU-1 GSE107734.RXRA.JMSU-1 266 bp overlap

ChIP JMSU-1_RXRA-S427F GSE107734.RXRA.JMSU-1_RXRA-S427F 237 bp overlap

Runx1 1 dataset

Motif DE_12h DE_12h-Runx1_MA0002.3 9 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 244 bp overlap

SIN3A 4 datasets

ChIP H1 ENCFF042ZSL 499 bp overlap

ChIP H1 ENCFF896IJG 301 bp overlap

ChIP WA01 ENCSR000EBO.SIN3A.WA01 277 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 120 bp overlap

SMAD2 2 datasets

Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 300 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 284 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 313 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 472 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 378 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 412 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 484 bp overlap

SMAD3 1 dataset

ChIP BG03 GSE21614.SMAD3.BG03 217 bp overlap

SMAD7 1 dataset

ChIP HepG2 ENCFF850FXR 85 bp overlap

SMARCA4 5 datasets

ChIP WA09 GSE105028.SMARCA4.WA09 256 bp overlap

ChIP WA09_heat-shock GSE105028.SMARCA4.WA09_heat-shock 303 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 502 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 468 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 464 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 465 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 464 bp overlap

SMARCC1 3 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 351 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 432 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 460 bp overlap

SOX2 3 datasets

ChIP hESC GSE18292.SOX2.hESC 96 bp overlap

ChIP hESC GSE69479.SOX2.hESC 198 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 391 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 358 bp overlap

ChIP WTC11 ENCFF688PEU 482 bp overlap

Stat6 1 dataset

Motif DE_12h DE_12h-Stat6_MA0520.2 10 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 128 bp overlap

TCF12 2 datasets

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 175 bp overlap

TCF7L1 1 dataset

Motif DE_12h DE_12h-TCF7L1_MA1421.1 12 bp overlap

TCF7L2 3 datasets

Motif DE_12h DE_12h-TCF7L2_MA0523.2 9 bp overlap

ChIP HCT-116_C16 GSE127960.TCF7L2.HCT-116_C16 187 bp overlap

ChIP HCT-116_sc2 GSE127960.TCF7L2.HCT-116_sc2 199 bp overlap

TEAD1 1 dataset

ChIP WTC11 ENCFF502QUV 405 bp overlap

TEAD4 1 dataset

ChIP H1 ENCFF778PAX 245 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 444 bp overlap

ChIP MDA-MB-231 GSE95303.TP53.MDA-MB-231 234 bp overlap

ChIP MDA-MB-231 GSE66081.YAP1.MDA-MB-231 248 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 148 bp overlap

ChIP HepG2 ENCFF016NZF 289 bp overlap

ZKSCAN5 1 dataset

Motif DE_12h DE_12h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF184 1 dataset

ChIP WTC11 ENCFF352POG 195 bp overlap

ZNF416 1 dataset

Motif DE_12h DE_12h-ZNF416_MA1979.2 10 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 244 bp overlap

ZNF501 1 dataset

ChIP HepG2 ENCFF879XZR 176 bp overlap

ZNF556 1 dataset

ChIP HepG2 ENCFF008WIK 265 bp overlap

ZNF607 1 dataset

ChIP HepG2 ENCFF118ANP 261 bp overlap

ZNF639 1 dataset

ChIP K562 ENCFF271FQR 146 bp overlap

ZNF746 1 dataset

ChIP HepG2 ENCFF056LOE 188 bp overlap

ZNF75D 1 dataset

Motif DE_12h DE_12h-ZNF75D_MA1601.2 12 bp overlap

ZNF770 1 dataset

ChIP HepG2 ENCFF233UVH 154 bp overlap

ZXDC 2 datasets

ChIP HepG2 ENCFF164JES 356 bp overlap

ChIP HepG2 ENCFF164JES 356 bp overlap