High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for HMGXB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMGXB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMGXB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:35,134,690–35,135,283 | 122.6 kb | Distal (>10kb) Multiome | 87 | |
| chr22:35,257,329–35,258,076 | 90 bp | At TSS Multiome | 851 | |
| chr22:35,299,271–35,300,787 | 42.5 kb | Distal (>10kb) Multiome | 908 | |
| chr22:35,350,767–35,351,264 | 93.5 kb | Distal (>10kb) Multiome | 589 | |
| chr22:35,371,784–35,372,565 | 114.6 kb | Distal (>10kb) Multiome | 874 | |
| chr22:35,376,743–35,377,378 | 119.6 kb | Distal (>10kb) Multiome | 810 | |
| chr22:35,399,845–35,400,552 | 142.6 kb | Distal (>10kb) Multiome | 740 | |
| chr22:35,539,918–35,540,941 | 282.9 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the HMGXB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.