This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for NFKB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFKB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFKB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,114,483–102,115,579 | 279.4 kb | Distal (>10kb) Multiome | 546 | |
| chr10:102,119,389–102,122,276 | 273.9 kb | Distal (>10kb) Multiome | 934 | |
| chr10:102,132,334–102,133,845 | 261.6 kb | Distal (>10kb) Multiome | 968 | |
| chr10:102,151,480–102,152,882 | 242.3 kb | Distal (>10kb) Multiome | 1009 | |
| chr10:102,169,504–102,169,976 | 224.8 kb | Distal (>10kb) Multiome | 398 | |
| chr10:102,225,881–102,226,551 | 168.3 kb | Distal (>10kb) Multiome HiCAR | 652 | |
| chr10:102,229,814–102,232,116 | 164.5 kb | Distal (>10kb) Multiome HiCAR | 689 | |
| chr10:102,240,581–102,242,031 | 152.9 kb | Distal (>10kb) Multiome | 504 | |
| chr10:102,244,918–102,246,010 | 149.1 kb | Distal (>10kb) Multiome | 734 | |
| chr10:102,393,940–102,396,107 | 1.2 kb | Proximal (<10kb) Multiome | 912 | |
| chr10:102,399,132–102,400,002 | 5.1 kb | Proximal (<10kb) Multiome | 832 | |
| chr10:102,403,842–102,404,078 | 9.3 kb | Proximal (<10kb) | 275 | |
| chr10:102,408,600–102,409,538 | 14.6 kb | Distal (>10kb) Multiome | 277 | |
| chr10:102,418,158–102,422,381 | 25.1 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:102,422,562–102,423,126 | 28.4 kb | Distal (>10kb) Multiome | 721 | |
| chr10:102,431,859–102,432,863 | 38.1 kb | Distal (>10kb) Multiome | 828 | |
| chr10:102,449,444–102,451,250 | 55.2 kb | Distal (>10kb) Multiome | 810 | |
| chr10:102,460,805–102,462,064 | 66.9 kb | Distal (>10kb) Multiome | 665 | |
| chr10:102,501,628–102,503,235 | 107.7 kb | Distal (>10kb) Multiome | 738 | |
| chr10:102,503,432–102,504,897 | 109.5 kb | Distal (>10kb) Multiome | 684 | |
| chr10:102,641,824–102,646,130 | 250.6 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 284.5 kb | Distal (>10kb) Multiome | 476 |
Genomic view of the NFKB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.