The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for USP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:8,621,400–8,622,171 | 342.2 kb | Distal (>10kb) Multiome | 736 | |
| chr16:8,660,694–8,661,275 | 302.8 kb | Distal (>10kb) Multiome | 325 | |
| chr16:8,673,966–8,674,850 | 289.4 kb | Distal (>10kb) Multiome | 585 | |
| chr16:8,797,340–8,798,108 | 166.2 kb | Distal (>10kb) Multiome | 1028 | |
| chr16:8,831,534–8,832,572 | 131.8 kb | Distal (>10kb) Multiome | 184 | |
| chr16:8,866,241–8,867,974 | 97.2 kb | Distal (>10kb) Multiome | 680 | |
| chr16:8,868,171–8,869,530 | 94.8 kb | Distal (>10kb) Multiome | 934 | |
| chr16:8,963,706–8,964,549 | 161 bp | At TSS Multiome | 663 | |
| chr16:8,965,943–8,966,445 | 2.3 kb | Proximal (<10kb) Multiome | 109 | |
| chr16:9,090,006–9,092,833 | 127.5 kb | Distal (>10kb) Multiome | 1125 | |
| chr16:9,107,648–9,108,299 | 144.1 kb | Distal (>10kb) Multiome | 24 | |
| chr16:9,184,033–9,184,598 | 220.4 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the USP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.