Enables ubiquitin protein ligase binding activity. Involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HAPSTR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAPSTR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAPSTR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:8,797,340–8,798,108 | 293.9 kb | Distal (>10kb) Multiome | 1028 | |
| chr16:8,831,534–8,832,572 | 259.5 kb | Distal (>10kb) Multiome | 184 | |
| chr16:8,866,241–8,867,974 | 225.0 kb | Distal (>10kb) Multiome | 680 | |
| chr16:8,868,171–8,869,530 | 222.6 kb | Distal (>10kb) Multiome | 934 | |
| chr16:8,963,706–8,964,549 | 127.6 kb | Distal (>10kb) Multiome | 663 | |
| chr16:8,965,943–8,966,445 | 125.5 kb | Distal (>10kb) Multiome | 109 | |
| chr16:9,090,006–9,092,833 | 193 bp | At TSS Multiome | 1125 | |
| chr16:9,095,576–9,095,868 | 3.9 kb | Proximal (<10kb) | 35 | |
| chr16:9,096,008–9,096,229 | 4.4 kb | Proximal (<10kb) | 23 | |
| chr16:9,107,648–9,108,299 | 16.4 kb | Distal (>10kb) Multiome | 24 | |
| chr16:9,184,033–9,184,598 | 92.6 kb | Distal (>10kb) Multiome | 41 | |
| chr16:9,370,057–9,370,636 | 278.7 kb | Distal (>10kb) Multiome | 59 |
Genomic view of the HAPSTR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.