Enables C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZXDC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZXDC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZXDC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:126,179,682–126,181,400 | 295.9 kb | Distal (>10kb) Multiome | 438 | |
| chr3:126,212,639–126,213,718 | 262.7 kb | Distal (>10kb) Multiome | 394 | |
| chr3:126,267,216–126,267,888 | 208.3 kb | Distal (>10kb) Multiome | 507 | |
| chr3:126,287,314–126,288,133 | 188.2 kb | Distal (>10kb) Multiome | 237 | |
| chr3:126,355,690–126,356,616 | 119.9 kb | Distal (>10kb) Multiome | 733 | |
| chr3:126,356,733–126,358,455 | 118.3 kb | Distal (>10kb) Multiome | 534 | |
| chr3:126,389,127–126,389,605 | 86.5 kb | Distal (>10kb) Multiome | 700 | |
| chr3:126,394,617–126,395,324 | 81.0 kb | Distal (>10kb) Multiome | 116 | |
| chr3:126,474,726–126,477,195 | 100 bp | At TSS Multiome | 733 | |
| chr3:126,523,848–126,524,758 | 48.4 kb | Distal (>10kb) Multiome | 575 | |
| chr3:126,654,554–126,655,321 | 179.2 kb | Distal (>10kb) Multiome | 582 | |
| chr3:126,679,144–126,679,651 | 203.6 kb | Distal (>10kb) Multiome | 342 | |
| chr3:126,703,722–126,704,881 | 228.2 kb | Distal (>10kb) Multiome | 711 | |
| chr3:126,751,552–126,752,720 | 276.5 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the ZXDC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.