This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for YAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:100,731,157–100,732,205 | 1378.8 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr11:101,914,433–101,915,676 | 195.4 kb | Distal (>10kb) Multiome | 805 | |
| chr11:102,047,223–102,047,965 | 63.0 kb | Distal (>10kb) Multiome | 355 | |
| chr11:102,109,725–102,112,204 | 205 bp | At TSS Multiome | 1075 | |
| chr11:102,114,119–102,114,384 | 3.7 kb | Proximal (<10kb) | 9 | |
| chr11:102,115,594–102,116,168 | 5.1 kb | Proximal (<10kb) | 276 | |
| chr11:102,119,043–102,119,282 | 8.6 kb | Proximal (<10kb) | 103 | |
| chr11:102,197,552–102,198,107 | 87.5 kb | Distal (>10kb) Multiome | 171 | |
| chr11:102,268,042–102,269,399 | 158.3 kb | Distal (>10kb) Multiome | 546 | |
| chr11:102,346,630–102,348,333 | 236.7 kb | Distal (>10kb) Multiome | 973 | |
| chr11:102,390,489–102,391,318 | 280.4 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the YAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.