Enables DNA-binding transcription repressor activity; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; and sprouting angiogenesis. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for E2F7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = E2F7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of E2F7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:76,780,975–76,782,664 | 283.6 kb | Distal (>10kb) Multiome | 241 | |
| chr12:76,872,409–76,872,961 | 193.0 kb | Distal (>10kb) Multiome | 106 | |
| chr12:76,878,056–76,880,114 | 186.5 kb | Distal (>10kb) Multiome | 765 | |
| chr12:77,064,730–77,066,404 | 83 bp | At TSS Multiome | 820 | |
| chr12:77,324,160–77,326,134 | 259.4 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the E2F7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.